WORKSHOP PAPER
Simulating the performance required for multi-tap charge modulation pixels in time-resolved biomedical imaging
Keiichiro Kagawa1,2, Nobukazu Teranishi1,3, Keita Yasutomi1, Rolf Saager2, Min-Woong Seo1, Shoji Kawahito1, Anthony Durkin2, Bruce Tromberg2
1Research Institute of Electronics, Shizuoka University, 3-5-1 Johoku, Nakaku, Hamamatsu, Shizuoka 432-8011, Japan
2Beckman Laser Institute, UC Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA
3Laboratory of Advanced Science and Technology for Industry, University of Hyogo, 1-1-2 Koto, Kamigori, Ako-gun, Hyogo 678-1205, Japan

Abstract

In this paper, the performance required for charge modulation pixels in typical biomedical applications based on time-resolved imaging are quantitatively estimated by simulation with modeling the detection process and compared with TCSPC as reference. Single-component fluorescence lifetime imaging (FLIM) and light scattering and absorption in tissues are discussed because quantitative measurement of metabolism based on autofluorescence of endogenous coenzymes and hemodynamics is of great interest in biomedical applications. Overall, accuracy of the deduced optical parameters is mostly determined by photon shot noise, which suggests that large full well capacity or multiple image acquisition is required. Low inter-tap crosstalk is more significant than low read noise when integrity is considered. Although multiple pixelwise signal image acquisition by shifting the tap timings can improve the performance, increase of the number of taps is more effective.
Publisher: IISS (Int. Image Sensors Society)
Year: 2017
Workshop: IISW
URL: https://doi.org/10.60928/qntc-6i59
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Keywords

time-resolved biomedical imaging, charge modulation pixels, fluorescence lifetime imaging (FLIM),

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